Interlaboratory comparison of serum vitamin B12 assay.

Interlaboratory comparison of serum vitamin B12 assay.

The results have been compared of microbiological and radioisotope dilution (RID) assay of serum vitamin B12 by participants in national interlaboratory trials in Britain. There was wide variation between the individual participants, especially marked in the L. leichmannii microbiological assay and in the RID methods, whereas excellent correlation, reproducibility, and recovery were obtained in...

Clinical application of serum vitamin B12 assay.

Comparison between Serum Holotranscobalamin and Total Vitamin B12 as Indicators of Vitamin B12 Status.

OBJECTIVES This study aims to assess the usefulness of serum holotranscobalamin (holoTC), the fraction of vitamin B12 that is available for tissue uptake, compared with total vitamin B12 in patients investigated for vitamin B12 disorders. METHODS Serum samples were randomly selected from 76 patients (48 females, 28 males; age range 12-69 years) referred to the Clinical Biochemistry Laboratory...

Chemiluminescence receptor assay for measuring vitamin B12 in serum evaluated.

We evaluated a chemiluminescence receptor assay for vitamin B12 in serum (Magic Lite; Ciba Corning Diagnostics), in which an acridinium ester label is used with magnetic particle separation. Within- and between-batch precisions were generally acceptable, except at low analyte concentrations. The reference range determined from 104 elective preoperative patients was 120-610 pmol/L, compared with...

Serum Acylcarnitines and Vitamin B12 Deficiency, Mark

Serum Acylcarnitines and Vitamin B12 Deficiency, Mark M. Kushnir, Bori Shushan, William L. Roberts, and Marzia Pasquali ( ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108; 2 MDS SCIEX, Concord, ON, L4K 4V8 Canada; 3 Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132; * author for correspondence: fax 801-584-5207, email kushnm...